Component Therapy

Blood Centers of the Pacific distributes a variety of blood components and derivatives. The various component categories are listed below, along with specific components and their commonality codes.

Many Transfusion Service staff have requested a guideline for the use of blood components. The most authoritative source is the most recent version of the Circular of Information (COI) for the Use of Blood and Blood Components.

This brochure is produced jointly by the AABB, America’s Blood Centers, and the American Red Cross. You can view the current version of the COI online here. Copies are also available from your Blood Centers of the Pacific location.

If you have questions concerning availability of particular blood components or special transfusion needs, please contact your blood center.

Blood Components

Red Blood Cells

One unit of red blood cells (RBC) contains approximately 200 mL red blood cells, 100 mL additive solution (AS-1, AS-3) and ~30 mL plasma. Additive solutions replace the majority of plasma from a whole blood unit and extend storage life of the unit. Some RBCs are available without the additive solution, with only anticoagulant present with the plasma (CPDA-1, CP2D, CPD). Each configuration contains the pertinent information on the product or component label. Expiration dating depends on the additive or anticoagulant present in the unit. RBCs must be stored at 1-6C.

Platelets

Apheresis leukocyte reduced platelets, collected from a single donor, are prepared in 200-400 mL of plasma, and contain a minimum yield of 3.0x 10″ platelets. Each pheresis unit is equivalent to 6-8 whole blood derived platelet concentrates and is usually an adequate dose for an average size adult. Platelets expire in 5 days or 7 days. The expiration date will be clear on the product label. Platelets must be stored between 20-24C with gentle agitation.

Blood Centers of the Pacific does not supply platelet concentrates produced from Whole Blood donations.

Platelets supplied by BCP have been screened for bacterial contamination and found to be negative in compliance with AABB Standard 5.1.5.1. Additional testing is not required by the Transfusion Facility.

Plasma Products

Several plasma component configurations are available. Anticoagulant and volume depend on the collection process. Plasma provided from whole blood donations contains approximately 250mL. Plasma provided from apheresis donations contains a minimum of 200 mL. Pediatric configurations can be provided from apheresis fresh frozen plasma products. Each unit contains the pertinent information on the component or product label.

Depending on center processes, plasma may be provided as:

  • Fresh Frozen Plasma (FFP)
  • Plasma Frozen within 24 Hours
  • Cryo-Reduced Plasma

Frozen expiration date is 365 days. Expiration dating of a thawed component depends on the type of plasma component. Thawed FFP must be transfused within 24 hour of thawing. Other thawed plasma products must be transfused within 5 days of thawing. Frozen plasma units must be stored at <-18C. Thawed plasma must be stored between 1-6C.

Cryoprecipitated Anti Hemophiliac Factor (Cryo, Cryoppt, Cryoprecipitate)

Cryo is prepared from plasma collected from a whole blood donation and contains Fibrinogen (>150 mg), von Willebrand Factor, Factor VIII (>80 IU), Factor XIII and Fibronectin. Cryo is the only adequate fibrinogen concentrate available for intravenous use. Each cryo unit contains approximately 15 mL plasma. Frozen expiration date is 365 days. Thawed cryo has an expiration date of 4 hours. Frozen cryo must be stored at <-18C. Thawed cryo must be stored at room temperature.

Granulocytes

Granulocytes prepared by apheresis are indicated for a very limited use. The Transfusion Facility must discuss use of this component with the BCP Medical Director to coordinate collection. Granulocytes have a short expiration time after collection (24 hours). They are stored at 20-24C without agitation.

Modified Blood Components

Leukocyte Reduced

Blood Centers of the Pacific routinely provides leukocyte reduced RBC and platelet components. An occasional special unit (e.g., autologous or HLA matched unit imported from another center or a deglycerolized RBC) may not be leukocyte reduced. If the unit is required to be transfused as leukocyte reduced then the transfusion facility must use a leukocyte reduction filter.

Irradiated

Patients at risk for developing graft-versus-host disease should receive irradiated cellular components:

  • Severely immunocompromised patients
  • Hematopoetic cell transplant candidates and recipients
  • Patients undergoing intrauterine transfusions
  • Recipients of donor directed components from a blood relative of the recipient
  • If the donor is selected for HLA compatibility by typing or cross-matching

Irradiated RBCs have a maximum expiration date of 28 days from irradiation. The BCP operating systems assigns irradiated blood components an expiration date that is 28-days from the date of COLLECTION after irradiation. If the unit has an expiration date less than 28 days prior to irradiation the shorter date must be used.

Volume Reduced

Removal of excess donor plasma from cellular components is indicated in selected patients who cannot tolerate the full volume or when ABO incompatible single donor platelets are transfused.

Approximately 10% of platelets are lost in this process and the extra centrifugation step may cause some platelet activation and loss of function. Volume Reduced platelets have a 4 hour expiration date.

Washed

Patients with severe life threatening plasma allergies uncontrolled by medications or volume reduction may require use of washed RBCs and Platelets. The units are suspended in saline, with very little plasma proteins remaining. Washed RBCs have a 24 hour expiration date. The recovery and function of platelets after washing are severely impaired. Washed platelets have a 4 hour expiration date.

Deglycerolized

RBCs may be frozen up to 10 years when their antigen makeup is considered ‘rare’ or for other special reasons. When a transfusion service requests antigen negative blood not found in liquid units, frozen units may be available. Through a process of deglycerolization, the cells are thawed and suspended in saline for transfusion. Deglycerolized RBCs have a 24 hour expiration date.

CMV sero-negative

CMV sero-negative cellular components are provided upon request. Both leukoreduced blood and CMV sero-negative blood have a much-reduced risk of transmitting CMV infection through transfusion.

Hemoglobin S negative

Patients with Sickle Cell Disease should be given Hemoglobin S negative RBCs.

Commonly Ordered Derivative Products

Rh Immune Globulin (Human)

Available in regular dose or microdose. The regular dose (1 mL) contains 300 mcgs of of immune globulin, which will protect against 15 mL of Rh positive RBCs (30 mL whole blood). The microdose may be used only after termination of pregnancy up to and including the 12th week of gestation.

Antihemophiliac Factor (AHF, Factor VIII)

Used for treatment of bleeding due to Hemophilia A. The dose is dependent upon the nature of the bleeding episode and severity of Factor VIII deficiency. The dose must be calculated. Several different formulations of recombinant and plasma derived Factor VIII are available. Refer to package insert for dosage and half-life specifics.

Factor IX, Factor VII

Several different kinds of Factors are available. Refer to package insert for dosage and half-life specifics.

Varicella Zoster Immune Globulin (Human)

Available in pediatric and adult dosages. Used for passive immunization of exposed, susceptible individuals who are at risk of complications from varicella infection.

Other derivatives are available upon request.

For more information please contact:
Andrew Lefevre
BioCare Representative
(714) 743-0749
alefevre@bloodsystems

Component List of Commonality Codes

Label Component List:
  • Words in italics are not part of the label text. They are for identification assistance.
  • “Bag” refers to an RBC component from an apheresis collection.
  • “Part” refers to a component containing divided in the title.
  • “Split” refers to a platelet pheresis split component.
  • If a version of this table with barcodes added is desired, contact your blood center.
Commonality Code Title
00150 CPD WHOLE BLOOD
00160 CPDA-1 WHOLE BLOOD
00250 CPD WHOLE BLOOD IRRADIATED
00260 CPDA-1 WHOLE BLOOD IRRADIATED
01450 CPD WHOLE BLOOD LEUKOCYTES REDUCED
01460 CPDA-1 WHOLE BLOOD LEUKOCYTES REDUCED
02450 CPD WHOLE BLOOD LEUKOCYTES REDUCED IRRADIATED
03311 AS-1 RED BLOOD CELLS ADENINE SALINE ADDED LEUKOCYTES REDUCE (ACD-A) (BAG-2)
03320 AS-1 RED BLOOD CELLS ADENINE-SALINE ADDED LEUKOCYTES REDUCED IRRADIATED (ACD-A) (BAG 1)
03330 AS-1 RED BLOOD CELLS ADENINE-SALINE ADDED LEUKOCYTES REDUCED IRRADIATED (ACD-A) (BAG 2)
03820 AS-1 RED BLOOD CELLS ADENINE-SALINE ADDED LEUKOCYTES REDUCED (ACD-A) (BAG 1)
04050 CPD RED BLOOD CELLS
04060 CDPA-1 RED BLOOD CELLS
04080 CP2D RED BLOOD CELLS
04210 AS-1 RED BLOOD CELLS
04230 AS-3 RED BLOOD CELLS
04241 AS-3 RED BLOOD CELLS (CP2D) (PHERESIS) (BAG 1)
04250 AS-5 RED BLOOD CELLS
04261 AS-3 RED BLOOD CELLS (CP2D) (PHERESIS) (BAG 2)
04271 AS-3 RED BLOOD CELLS (ACD-A) (PHERESIS) (BAG 1)
04281 AS-3 RED BLOOD CELLS (ACD-A) (PHERESIS) (BAG 2)
04350 CPD RED BLOOD CELLS LEUKOCYTES REDUCED
04360 CPDA-1 RED BLOOD CELLS LEUKOCYTES REDUCED
04380 CP2D RED BLOOD CELLS LEUKOCYTES REDUCED
04710 AS-1 RED BLOOD CELLS LEUKOCYTES REDUCED
04730 AS-3 RED BLOOD CELLS LEUKOCYTES REDUCED
04741 AS-3 RED BLOOD CELLS LEUKOCYTES REDUCED (CP2D) (PHERESIS) (BAG 1)
04750 AS-5 RED BLOOD CELLS LEUKOCYTES REDUCED
04761 AS-3 RED BLOOD CELLS LEUKOCYTES REDUCED (CP2D) (PHERESIS) (BAG 2)
04771 AS-3 RED BLOOD CELLS LEUKOCYTES REDUCED (ACD-A) (PHERESIS) (BAG 1)
04791 AS-3 RED BLOOD CELLS LEUKOCYTES REDUCED (ACD-A) (PHERESIS) (BAG 2)
04900 RED BLOOD CELLS WASHED
04941 RED BLOOD CELLS WASHED (PHERESIS) (BAG 1)
04961 RED BLOOD CELLS WASHED (PHERESIS) (BAG 2)
05050 CPD RED BLOOD CELLS IRRADIATED
05060 CPDA-1 RED BLOOD CELLS IRRADIATED
05210 AS-1 RED BLOOD CELLS IRRADIATED
05230 AS-3 RED BLOOD CELLS IRRADIATED
05241 AS-3 RED BLOOD CELLS IRRADIATED (CP2D) (PHERESIS) (BAG 1)
05250 AS-5 RED BLOOD CELLS IRRADIATED
05261 AS-3 RED BLOOD CELLS IRRADIATED (CP2D) (PHERESIS) (BAG 2)
05271 RED BLOOD CELLS IRRADIATED (PHERESIS) (BAG 1)
05281 RED BLOOD CELLS IRRADIATED (PHERESIS) (BAG 2)
05350 CPD RED BLOOD CELLS LEUKOCYTES REDUCED IRRADIATED
05360 CPDA-1 RED BLOOD CELLS LEUKOCYTES REDUCED IRRADIATED
05380 CP2D RED BLOOD CELLS LEUKOCYTES REDUCED IRRADIATED
05710 AS-1 RED BLOOD CELLS LEUKOCYTES REDUCED IRRADIATED
05730 AS-3 RED BLOOD CELLS LEUKOCYTES REDUCED IRRADIATED
05741 AS-3 RED BLOOD CELLS LEUKOCYTES REDUCED IRRADIATED (CP2D) (PHERESIS) (BAG 1)
05750 AS-5 RED BLOOD CELLS LEUKOCYTES REDUCED IRRADIATED
05761 AS-3 RED BLOOD CELLS LEUKOCYTES REDUCED IRRADIATED (CP2D) (PHERESIS) (BAG 2)
05771 AS-3 RED BLOOD CELLS LEUKOCYTES REDUCED IRRADIATED (ACD-A) (PHERESIS) (BAG 1)
05781 AS-3 RED BLOOD CELLS LEUKOCYTES REDUCED IRRADIATED (ACD-A) (PHERESIS) (BAG 2)
05900 RED BLOOD CELLS WASHED IRRADIATED
06041 RED BLOOD CELLS LEUKOCYTES REDUCED WASHED (PHERESIS) (BAG 1)
06061 RED BLOOD CELLS LEUKOCYTES REDUCED WASHED (PHERESIS) (BAG 2)
06100 RED BLOOD CELLS LEUKOCYTES REDUCED WASHED IRRADIATED
06141 RED BLOOD CELLS LEUKOCYTES REDUCED WASHED (PHERESIS) (BAG 1)
06161 RED BLOOD CELLS LEUKOCYTES REDUCED WASHED (PHERESIS) (BAG 2)
06400 RED BLOOD CELLS DEGLYCEROLIZED
06411 RED BLOOD CELLS DEGLYCEROLIZED (PHERESIS) (BAG 1)
06451 RED BLOOD CELLS DEGLYCEROLIZED (PHERESIS) (BAG 2)
06500 RED BLOOD CELLS REJUVENATED DEGLYCEROLIZED
06600 RED BLOOD CELLS REHUJEVNATED WASHED
06700 RED BLOOD CELLS LEUKOCYTES REDUCED FROZEN
06711 RED BLOOD CELLS FROZEN (PHERESIS) (BAG 1)
06761 RED BLOOD CELLS FROZEN (PHERESIS) (BAG 2)
06780 RED BLOOD CELLS LEUKOCYTES REDUCED FROZEN REJUVENATED
06800 RED BLOOD CELLS LEUKOCYTES REDUCED DEGLYCEROLIZED
06880 RED BLOOD CELLS LEUKOCYTES REDUCED DEGLYCEROLIZED REJUVENATED
07200 RED BLOOD CELLS FROZEN IRRADIATED
07400 RED BLOOD CELLS DEGLYCEROLIZED IRRADIATED
07411 RED BLOOD CELLS DEGLYCEROLIZED IRRADIATED (PHERESIS) (BAG 1)
07451 RED BLOOD CELLS DEGLYCEROLIZED IRRADIATED (PHERESIS) (BAG 2)
07500 RED BLOOD CELLS REJUVENATED DEGLYCEROLIZED IRRADIATED
07600 RED BLOOD CELLS REJUVENATED IRRADIATED
07731 RED BLOOD CELLS LEUKOCYTES REDUCED FROZEN IRRADIATED (PHERESIS) (BAG 1)
07741 RED BLOOD CELLS LEUKOCYTES REDUCED FROZEN IRRADIATED (PHERESIS) (BAG 2)
07780 RED BLOOD CELLS DEGLYCEROLIZED IRRADIATED
07841 RED BLOOD CELLS LEUKOCYTES REDUCED DEGLYCEROLIZED IRRADIATED (PHERESIS) (BAG 1)
07851 RED BLOOD CELLS LEUKOCYTES REDUCED DEGLYCEROLIZED IRRADIATED (PHERESIS) (BAG 2)
07880 RED BLOOD CELLS LEUKOCYTES REDUCED REJUVENATED DEGLYCEROLIZED IRRADIATED
10100 CRYOPRECIPITATED
10151 CRYOPRECIPITATED
10152 CRYOPRECIPITATED
10153 CRYOPRECIPITATED
10191 CAF POOLED
12000 PLATELET CONCENTRATE
12001 PLATELET CONCENTRATE CONTENTS VARIABLE
12010 Platelets Pheresis (VARIABLE ANTICOAGULANTS)
12011 Platelets Pheresis (VARIABLE CONTENTS AND ANTICOAGULANTS)
12050 PLATELETS PHERESIS (ACD-A) (SPLIT 2)
12070 PLATELETS LEUKOCYTES REDUCED (CPD OR CP2D)
12071 PLATELETS LEUKOCYTES REDICED (VARIABLE CONTENTS) (CP2D)
12080 PLATELETS PHERESIS (ACD-A) (SPLIT 3)
12090 PLATELET CONCENTRATE WASHED
12600 PLATELETS IRRADIATED (CPD)
12610 Platelets Pheresis IRRADIATED (VARIABLE ANTICOAGULANTS)
12611 PLATELETS PHERESIS IRRADIATED (ACD-A) (VARIABLE CONTENTS)
12650 PLATELETS PHERESIS IRRADIATED (ACD-A) (SPLIT 2)
12670 PLATELETS LEUKOCYTES REDUCED IRRADIATED (CP2D)
12671 PLATELETS LEUKOCYTES REDUCED IRRADIATED (CP2D) (VARIABLE CONTENTS)
12680 PLATELETS PHERESIS IRRADIATED (ACD-A) (SPLIT 3)
12710 PLATELETS PHERESIS LEUKOCYTES REDUCED (NON-SPLIT OR SPLIT 1)
12711 PLATELETS PHERESIS LEUKOCYTES REDUCED (ACD-A) (VARIABLE CONTENTS)
12750 PLATELETS PHERESIS LEUKOCYTES REDUCED (ACD-A) (SPLIT 2)
12780 PLATELETS PHERESIS LEUKOCYTES REDUCED (ACD-A) (SPLIT 3)
12810 PLATELETS PHERESIS LEUKOCYTES REDUCED IRRADIATED (VARIABLE ANTICOAGULANTS)
12811 PLATELETS PHERESIS LEUKOCYTES REDUCED IRRADIATED (ACD-A) (VARIABLE CONTENTS)
12850 PLATELETS PHERESIS LEUKOCYTES REDUCED IRRADIATED (ACD-A) (SPLIT 2)
12880 PLATELETS PHERESIS LEUKOCYTES REDUCED IRRADIATED (ACD-A) (SPLIT 3)
16401 GRANULOCYTES
16411 GRANULOCYTES PHERESIS
18101 PLASMA FROZEN WITHIN 24 HOURS AFTER PHLEBOTOMY (VARIABLE ANTICOAGULANTS)
18201 FRESH FROZEN PLASMA (VARIABLE ANTICOAGULANTS)
18211 FRESH FROZEN PLASMA (ACD-A OR CP2D) (PHERESIS)
18212 FRESH FROZEN PLASMA (ACD-A OR CP2D) (PHERESIS) (BAG 2)
18251 FRESH FROZEN PLASMA (ACD-A OR CP2D) (APHERESIS)
18401 PLASMA
18435 PLASMA CRYOPRECIPITATE REDUCED
18501 LIQUID PLASMA
27050 RED BLOOD CELLS (CPD) (AUTOLOGOUS)
27071 FRESH FROZEN PLASMA (AUTOLOGOUS)
27110 RED BLOOD CELLS (AS-1) (AUTOLOGOUS)
27161 WHOLE BLOOD (AUTOLOGOUS)
27161 WHOLE BLOOD (CPDA-1) (AUTOLOGOUS)
27166 RED BLOOD CELLS WASHED REJUVENATED (AUTOLOGOUS)
27200 RED BLOOD CELLS FROZEN (AUTOLOGOUS)
27211 SINGLE DONOR PLATELET WASHED (PHERESIS) (BAG 1)
27212 SINGLE DONOR PLATELET WASHED (PHERESIS) (BAG 2)
27213 SINGLE DONOR PLATELET WASHED (PHERESIS) (BAG 3)
27214 SINGLE DONOR PLATELET VOLUME REDUCED (PHERESIS) (BAG 1)
27215 SINGLE DONOR PLATELET VOLUME REDUCED (PHERESIS) (BAG 2)
27216 SINGLE DONOR PLATELET VOLUME REDUCED (PHERESIS) (BAG 3)
27260 RED BLOOD CELLS (CPDA-1) (AUTOLOGOUS)
27266 RED BLOOD CELLS WASHED (AUTOLOGOUS)
27300 RED BLOOD CELLS FROZEN REJUVENATED (AUTOLOGOUS)
27400 RED BLOOD CELLS DEGLYCEROLIZED (AUTOLOGOUS)
27500 RED BLOOD CELLS DEGLYCEROLIZED REJUVENATED (AUTOLOGOUS)
27771 FIBRIN ADHESIVE (AUTOLOGOUS)
27901 SINGLE DONOR PLATELET VOLUME REDUCED IRRADIATED (PHERESIS) (BAG 1)
27902 SINGLE DONOR PLATELET VOLUME REDUCED IRRADIATED (PHERESIS) (BAG 2)
27903 SINGLE DONOR PLATELET VOLUME REDUCED IRRADIATED (PHERESIS) (BAG 3)
27911 SINGLE DONOR PLATELET WASHED IRRADIATED (PHERESIS) (BAG 1)
27912 SINGLE DONOR PLATELET WASHED IRRADIATED (PHERESIS) (BAG 2)
27913 SINGLE DONOR PLATELET WASHED IRRADIATED (PHERESIS) (BAG 3)
34061 CPDA-1 RED BLOOD CELLS DIVIDED (PART 1)
34062 CPDA-2 RED BLOOD CELLS DIVIDED (PART 2)
34063 CPDA-1 RED BLOOD CELLS DIVIDED (PART 3)
34361 CPDA-1 RED BLOOD CELLS LEUKOCYTES REDUCED DIVIDED (PART 1)
34362 CPDA-1 RED BLOOD CELLS LEUKOCYTES REDUCED DIVIDED (PART 2)
34363 CPDA-1 RED BLOOD CELLS LEUKOCYTES REDUCED DIVIDED (PART 3)
35061 CPDA-1 RED BLOOD CELLS IRRADIATED DIVIDED (PART 1)
35062 CPDA-1 RED BLOOD CELLS IRRADIATED DIVIDED (PART 2)
35063 CPDA-1 RED BLOOD CELLS IRRADIATED DIVIDED (PART 3)
35361 CPDA-1 RED BLOOD CELLS LEUKOCYTES REDUCED IRRADIATED DIVIDED (PART 1)
35362 CPDA-1 RED BLOOD CELLS LEUKOCYTES REDUCED IRRADIATED DIVIDED
35363 CPDA-1 RED BLOOD CELLS LEUKOCYTES REDUCED IRRADIATED DIVIDED
48201 FRESH FROZEN PLASMA DIVIDED (CPD OR CP2D) (PART 1)
48202 FRESH FROZEN PLASMA DIVIDED (CPD OR CP2D) (PART 2)
48203 FRESH FROZEN PLASMA DIVIDED (CPD OR CP2D) (PART 3)
48204 FRESH FROZEN PLASMA DIVIDED (CPD OR CP2D) (PART 4)
48211 FRESH FROZEN PLASMA DIVIDED (ACD-A OR CP2D) (PHERESIS) (PART 1)
48212 FRESH FROZEN PLASMA DIVIDED (ACD-A OR CP2D) (PHERESIS) (PART 2)
48213 FRESH FROZEN PLASMA DIVIDED (ACD-A OR CP2D) (PHERESIS) (PART 3)
48214 FRESH FROZEN PLASMA DIVIDED (ACD-A OR CP2D) (PHERESIS) (PART 4)
48215 FRESH FROZEN PLASMA DIVIDED (ACD-A) (PHERESIS) (PART 5)
50000 PLATELETS PHERESIS -7d LEUKOCYTES REDUCED
50001 PLATELETS PHERESIS-7d LEUKOCYTES REDUCED (ACD-A) (SPLIT 2)
50002 PLATELETS PHERESIS – 7d LEUKOCYTES REDUCED (ACD-A) (SPLIT 3)
50003 PLATELETS PHERESIS – 7d LEUKOCYTES REDUCED IRRADIATED (ACD-A) (NON-SPLIT OR SPLIT 1)
50004 PLATELETS PHERESIS – 7d LEUKOCYTES REDUCED IRRADIATED (ACD-A) (SPLIT 2)
50005 PLATELETS PHERESIS – 7d LEUKOCYTES REDUCED IRRADIATED (ACD-A) (SPLIT 3)
50054 PLATELETS PHERESIS – 7d LEUKOCYTES REDUCED (ACD-A) (VARIABLE CONTENTS)
50055 PLATELETS PHERESIS – 7d LEUKOCYTES REDUCED IRRADIATED (ACD-A) (VARIABLE CONTENTS)